March 30, 2019
March 30, 2019
Local breakthrough research has shown the capability of cells to eliminate malignant tumors induced by hepatitis B after cellular reprogramming.
In this study, autologous T cells from two patients with recurrence of HCC post liver transplantation were engineered to express TCRs specific for epitopes expressed from HBV-DNA in patients’ metastases. The treatment was well tolerated without notable adverse events in these two patients. Importantly, in one patient, 5 of 6 pulmonary metastases decreased in volume during the 1-year period of T-cell administration. This encouraging clinical data was published in Gastroenterology (Tan et al,2019).
The research was conducted in collaboration with Duke-National University ofSingapore School of Medicine (Duke-NUS), Singapore General Hospital, and LionTCR. - Lianhe Zaobao
Lion TCR Licenses and Duke-NUS Medical School ink an exclusive IP licensing agreement for Immunosuppressive Drug Resistant Anti-Cancer T-cells
Dr Wai Lu-En, Director of R&D, represented Lion TCR to share the latest developments to the Minister for Manpower and Second Minister for Trade and Industry Tan See Leng.
Scientific Founder, Prof Antonio Bertoletti Appointed in Cell and Gene Therapy Workgroup in Singapore
Lion TCR Announces Data Presentation for its lead T-cell product, LioCyx-M at EASL Digital Liver Cancer Summit 2021
HSA approval for Phase 1 IND clinical trial for Lion TCR’s lead product LioCyx-M to characterize changes in liver cancer tumor microenvironment
Lion TCR presents two abstracts of Phase 1 clinical trial data for lead product LioCyx-M at the 2020 Society for Immunotherapy of Cancer (SITC) Annual Meeting
Companion diagnostic assay for personalised immunotherapy for HBV-related liver cancer featured in A*STAR GIS website
Singapore’s first clinical trial approval for T cell engineered (TCR) immunotherapy for treatment of Liver cancer
Lion TCR receives US$ 20 million to fund its personalized T cell therapy clinical trials against Liver cancer
Scientific Founder, Prof. Antonio Bertoletti and Scientific Consultant, Dr Anthony Tanoto Tan of Lion TCR were awarded the SingHealth Duke-NUS Research Award 1st Prize 2018
US FDA grants Lion TCR two orphan drug designations of T cell therapy against Hepatocellular Carcinoma
New publication – Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient