March 30, 2019
March 30, 2019
Local breakthrough research has shown the capability of cells to eliminate malignant tumors induced by hepatitis B after cellular reprogramming.
In this study, autologous T cells from two patients with recurrence of HCC post liver transplantation were engineered to express TCRs specific for epitopes expressed from HBV-DNA in patients’ metastases. The treatment was well tolerated without notable adverse events in these two patients. Importantly, in one patient, 5 of 6 pulmonary metastases decreased in volume during the 1-year period of T-cell administration. This encouraging clinical data was published in Gastroenterology (Tan et al,2019).
The research was conducted in collaboration with Duke-National University ofSingapore School of Medicine (Duke-NUS), Singapore General Hospital, and LionTCR. - Lianhe Zaobao
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US FDA grants Lion TCR two orphan drug designations of T cell therapy against Hepatocellular Carcinoma
Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient