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To discover, develop and commercialize first-in-class & best-in-class TCR T cell therapy against viral infections and their related cancers

To cure viral-related diseases through the science of immunotherapies

About us

For the past decade, we have accumulated expertise covering the entire product development process, ranging from basic research, T cell engineering and development, and preclinical/clinical trial and assessment. 

Led by industry and academic experts from our base in Singapore, we are dedicated to the commercialization and continued development of our immunotherapy products in the world.

Antonio BERTOLETTI, MD
Antonio BERTOLETTI, MD

Scientific Founder​ & Chairman

Prof Antonio Bertoletti is named top 0.1% Hepatitis B Expert in the World over the past 10 years (Expertscape in 2019). He was the Director of Infection and Immunity Program at the Singapore Institute for Clinical Sciences (SICS) under A*STAR until 2013.​ Currently, he is a professor in the Division Emerging Infectious Diseases at Duke-NUS Graduate Medical School. Prof Antonio was trained as a specialist in Infectious Diseases and has always been interested in immunological control of persistent viral infections, particularly Hepatitis B (HBV). His current research focuses on the development of new immunological based therapies (TCR-redirected T cells, HLA-peptide specific antibodies) for the treatment of HBV and Hepatocellular carcinoma (HCC), and the characterization of human intra-sinusoidal hepatic immune system. Prof Antonio and his team have received the 1st Prize Award based on the first in the world using HBV-specific TCR-T for liver cancer. He has been holding scientific advisor role for Gilead, MedImmune, Vir Biotechnology and Janssen. To learn more about his lab: http://www.bertolettilab.com
Xiaoming PENG, PhD, MBA
Xiaoming PENG, PhD, MBA

Chief Executive Officer

Dr Peng obtained his PhD degree from National University of Singapore (NUS) and holds Adjunct Associate Professor at NUS, he has over 18 years working experience at A*STAR holding senior positions including Head of Division & Senior Scientist, Deputy Director of the Strategic Planning for China.​ With over two decades of experience in R&D and team management, he has accumulated tens of millions research grants and funding from industry partners.
Tina WANG, MD, PhD
Tina WANG, MD, PhD

Chief Operating Officer

Dr Wang is a medical doctor. She obtained her PhD degree from National University of Singapore (NUS), and has over 20 years experience in the field of oncology in biopharmaceutical industry, clinical practice and translational medical research. She led the Asia Pacific medical team for the successful pre-launch and launch of VENTANA PD-L1 assays (SP142 and SP263) at Roche Diagnostics APAC. She has driven the advanced CD30 CAR-T cell therapy into clinical trials and led the FDA IND clearance to treat lymphoma patients at Tessa Therapeutics.

Anthony TAN, PhD
Anthony TAN, PhD

Scientific consultant

Dr Anthony has over 9 years of extensive experience in immunology and virology at Dr. Antonio Bertoletti’s laboratory. He obtained his Ph.D. from the National University of Singapore in 2012 and is experienced in the selection of antigen targets in viral infection-related cancer, the construction of T cell receptors, and in conducting preclinical research in animal models.

Sarene KOH, PhD
Sarene KOH, PhD

Director of Technology and Manufacturing Department

Dr Koh was an A*STAR scholar and obtained her PhD in Medical Science from Karolinska Institute, Sweden in 2013. She was a post-doctoral fellow in the laboratory of Professor Antonio Bertoletti at Singapore Institute for Clinical Sciences (SICS) of A*STAR. Her current R&D and product development interests are focused on T-cell immunotherapy and the immuno-pathogenesis of hepatitis B virus infection. Since 2017, she has led Lion TCR's efforts on product development and process optimisation in T cell immuno-therapy and the immuno-pathogenesis of hepatitis B virus infection.

Lu-En WAI, PhD
Lu-En WAI, PhD

Director of Research and Development Department

Dr Wai was an A*STAR scholar with over 15 years of experience in immunology research, in the fields of transplantation, cancer and HBV immunopathogenesis. She obtained her Ph.D. in Immunology from Stanford University, U.S.A. in 2010, focusing on immune cell interactions in liver transplantation and cancer. Since 2017, Dr Wai has led Lion TCR’s efforts to expand the TCR library and pipeline project.

Tee Wee WONG, PhD
Tee Wee WONG, PhD

Director of GMP Operation Department

Dr Wong has over 20 years of industry experiences in  Manufacturing, Regulatory Affairs, Quality Assurance and Quality Control in pharmaceutical start-ups as well as a Regulatory Consultant with the Health Sciences Authority (HSA). ​He obtained PhD in Pharmacology from University of Sydney (1997).
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