HomeCompanyTechnologyPipelinePatientsInvestors & MediaCareersContact

At Lion TCR

We hunt virus by harnessing the power of a patient’s own immune system to eliminate Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), with proven clinical safety and efficacy.

Our proprietary personalized TCR-T cell therapy has been applied in clinics for
• HBV related HCC
• Recurrent HCC post liver transplant • Chronic HBV infection


Largest patented TCR library in the world

Our library of HBV-specific TCRs covers about 80% of the patient population with a broad range of HLA types, particularly those predominant in Asia where HBV is prevalent.

mRNA technology

Transient expression of our TCR on T-cells confers enhanced safety features which allows for a conservative dose escalation design in clinical trials and future use for other cancer treatment.

State-of-the-art GMP production facility

A comprehensive facility for the manufacturing of our proprietary product for clinical use in compliance with Good-Manufacturing-Practice (GMP) guidelines.

Proven clinical safety and efficacy

A safer personalized treatment providing an approximately 3-fold increase in survival time compared to existing standard of care medication for liver cancer patients in our Phase 1 studies.


Our TCR-T cell therapy harnesses the patient’s own immune system to fight against viral infections and related cancers.


We are conducting ongoing clinical trials against hepatocellular carcinoma (HCC) to evaluate the safety and efficiacy of our TCR-T cells.

Investors & Media

Our proprietary TCR-T cell therapy platform is supported by robust research, in collaboration with renowned laboratories, in the areas of  TCR discovery platform, autologous & allogeneic TCR T cell platform and gene editing technologies.

R&D Partners

Industry Partners

Hospital Sites

Lion TCR News