July 4, 2023
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Lion TCR Secures USD 40 million Series B2 Financing, Revolutionizing Solid Tumor Treatment with mRNA-Encoding TCR-T Cell Therapy
Focusing on the development of T cell receptor (TCR)-T cell therapy against life-threatening viral infections and viral-related cancers pertinent in Asia.
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We hunt virus by harnessing the power of a patient’s own immune system to eliminate Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), with proven clinical safety and efficacy.
Our proprietary personalized TCR-T cell therapy has been applied in clinics for
• HBV related HCC
• Recurrent HCC post liver transplant • Chronic HBV infection
Our library of HBV-specific TCRs covers about 80% of the patient population with a broad range of HLA types, particularly those predominant in Asia where HBV is prevalent.
Transient expression of our TCR on T-cells confers enhanced safety features which allows for a conservative dose escalation design in clinical trials and future use for other cancer treatment.
A comprehensive facility for the manufacturing of our proprietary product for clinical use in compliance with Good-Manufacturing-Practice (GMP) guidelines.
A safer personalized treatment providing an approximately 3-fold increase in survival time compared to existing standard of care medication for liver cancer patients in our Phase 1 studies.
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Our TCR-T cell therapy harnesses the patient’s own immune system to fight against viral infections and related cancers.
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We are conducting ongoing clinical trials against hepatocellular carcinoma (HCC) to evaluate the safety and efficiacy of our TCR-T cells.
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Our proprietary TCR-T cell therapy platform is supported by robust research, in collaboration with renowned laboratories, in the areas of TCR discovery platform, autologous & allogeneic TCR T cell platform and gene editing technologies.
